Maternal Hyperthyroidism - Milk Ejections: What is the Association? - Juniper Publishers
Trends in Technical & Scientific Research - Juniper Publishers Commentary The regular balance in the activity of the maternal Hypothalamic-Pituitary-Thyroid Axis (HPTA) is vital for the normal progress of fetuses and neonates [1-50], especially the concentration of the Prolactin (PRL) [51-68]. In addition, the placental hormones, ovarian steroids, and neurotransmitter systems including the opioid, adrenergic, dopaminergic, serotonergic can regulate the release of PRL during the gestation and lactation [69-75]. More interestingly, in the transition from the late gestation to lactation, the expression of tyrosine hydroxylase mRNA was diminished gradually to maintain the hyperprolactinemia during the lactation and suckling process [76-85]. On the other hand, the previous observations have shown the link between the hyperthyroidism and delaying the milk ejections and suckling process [86-90]. Administration of 1 or 0.25mg/kg/day Thyroxine (T4) to rats ...